This data set comes from a study carried out at the University of Iowa investigating the genetic causes of primary open-angle glaucoma (GLC) and age-related macular degeneration (AMD). In the study, 400 AMD patients and 400 GLC patients were recruited, and their genotype determined at roughly 500,000 genetic loci. The idea here is that each group could serve as the control group group for the other disease.
This is a subset of the data; it does not consider all 500,000 genetic loci, but rather a subset of 497 SNPs from 30 genes that have been previously suggested may play a role in AMD.
y: Disease status: either 'glc' or 'amd'x: SNP genotype (0/1/2)group: For each SNP, this is the nearest gene. There are 30 genes
altogether.Scheetz TE, Fingert JH, Wang K, Kuehn MH, Knudtson KL, Alward WLM, Boldt HC, Russell SR, Folk JC, Casavant TL Braun TA, Clark AF, Stone EM, and Sheffield VC (2013). A Genome-Wide Association Study for Primary Open Angle Glaucoma and Macular Degeneration Reveals Novel Loci. PLOS ONE 8: e58657. https://doi.org/10.1371/journal.pone.0058657