Scherzer2007 code copied

Biomarkers for early detection of Parkinson's disease

Dimension

• 105 instances (rows)
• 22283 features (columns)

Description

The goal of the study was to try to identify biomarkers capable of identifying people in the early stages of Parkinson’s disease, before clinical symptoms develop.

In the study, blood samples were extracted from 50 patients with Parkinson’s disease, predominantly in the early stages of their disease, as well as 55 controls, many of which with other neurological diseases such as Alzheimer’s disease that may be misclassified as Parkinson’s.

For each patient, the expression levels of 22,283 genes were measured using microarrays.

Elements

• y: Case/control status (Case, Control)
• X: Gene expression measurements

Annotation

• Rows of X, and elements of y, are annotated with arbitrary, matching sample labels.
• Columns of X are labeled with the Gene Symbol.

Reference

Scherzer CR, Eklund AC, Morse LJ, Liao Z, Locascio JJ, Fefer D, Schwarzschild MA, Schlossmacher MG, Hauser MA, Vance JM, Sudarsky LR, Standaert DG, Growdon JH, Jensen RV, and Gullans SR (2007). Molecular markers of early Parkinson’s disease based on gene expression in blood. Proceedings of the National Academy of Sciences, 104: 955-960. https://doi.org/10.1073/pnas.0610204104.