Golub1999 code copied

Gene expression in leukemia patients

Dimension

Background

This data set consists of 47 patients with acute lymphoblastic leukemia (ALL) and 25 patients with acute myeloid leukemia (AML). Each of the 72 patients had bone marrow samples obtained at the time of diagnosis. Gene expression measurements for the samples were taken using Affymetrix Hgu6800 chips, resulting in 7129 measurements per patient.

Of the two diseases, AML has a considerably worse prognosis: only 26% survive at least 5 years following diagnosis, compared to 68% for ALL (source).

Format

Annotation

Source

I obtained the data from the golubEsets package, used the vsn package for normalization, and the hu6800.db package for annotation.

Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, and Lander ES (1999). Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science, 286:531-537.